Dose-Response Relationship after Immunization of Volunteers with a New, Surface-Antigen-Adsorbed Influenza Virus Vaccine
Identifieur interne : 002A71 ( Main/Exploration ); précédent : 002A70; suivant : 002A72Dose-Response Relationship after Immunization of Volunteers with a New, Surface-Antigen-Adsorbed Influenza Virus Vaccine
Auteurs : C. W. Potter [Royaume-Uni] ; R. Jennings [Royaume-Uni] ; J. P. Phair [Royaume-Uni] ; A. Clarke [Royaume-Uni] ; C. H. Stuart-Harris [Royaume-Uni]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1977.
Abstract
Volunteers (15 per group) were given inoculations of various .doses (5–400 international units [IU]) of surface-antigen-adsorbed influenza virus A/Port Chalmers/ 73 vaccine; this vaccine was prepared from purified virus hemagglutinin and neuraminidase antigens and adsorbed to alhydrogel. The titers of hemagglutinationinhibiting (HAl) and neuraminidase-inhibiting antibodies in serum after immunization showed a clear dose-response relationship. Thus, for volunteers given 400, 100, 25, or 5.0 IV of vaccine, the titers of HAl antibody in serum increased 174−, 32−, 12−, and eightfold, respectively. A similar dose response was observed for production of local neutralizing antibody. Immunization with A/Port Chalmers/73 virus vaccine also induced serum HAl antibody to influenza viruses A/Scotland/74, A/England/ 72, and A/Hong Kong/68; the increase in titers of antibody to these viruses corresponded directly to the degree of cross-reactivity between the virus tested and the vaccine virus. Four weeks after immunization, all volunteers were challenged with attenuated WRL-I05 influenza virus. Evidence of viral infection was found in one, two, and two volunteers in each group of IS subjects previously immunized with 400, 100, and 25 IV of vaccine, respectively; in six of the IS volunteers given 5.0 IV of vaccine; and in lOaf 15 control subjects. The results suggest that equivalent immunity was induced in volunteers given ⩾25 IV of vaccine.
Url:
DOI: 10.1093/infdis/135.3.423
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Dose-Response Relationship after Immunization of Volunteers with a New, Surface-Antigen-Adsorbed Influenza Virus Vaccine</title><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name></author><author><name sortKey="Phair, J P" sort="Phair, J P" uniqKey="Phair J" first="J. P." last="Phair">J. P. Phair</name></author><author><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A." last="Clarke">A. Clarke</name></author><author><name sortKey="Stuart Harris, C H" sort="Stuart Harris, C H" uniqKey="Stuart Harris C" first="C. H." last="Stuart-Harris">C. H. Stuart-Harris</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DC15A921EA2E697AC8AEFD84E4AF6A99FD473978</idno><date when="1977" year="1977">1977</date><idno type="doi">10.1093/infdis/135.3.423</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-VBPH6Z7C-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000935</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000935</idno><idno type="wicri:Area/Istex/Curation">000935</idno><idno type="wicri:Area/Istex/Checkpoint">001649</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001649</idno><idno type="wicri:doubleKey">0022-1899:1977:Potter C:dose:response:relationship</idno><idno type="wicri:Area/Main/Merge">002C32</idno><idno type="wicri:Area/Main/Curation">002A71</idno><idno type="wicri:Area/Main/Exploration">002A71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dose-Response Relationship after Immunization of Volunteers with a New, Surface-Antigen-Adsorbed Influenza Virus Vaccine</title><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, Yorkshire</wicri:cityArea></affiliation><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Please address requests for reprints to Prof. C. W. Potter, Department of Virology, University of Sheffield Medical School, Beech Hill Road, Sheffield SIO 2RX, Yorkshire</wicri:cityArea></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, Yorkshire</wicri:cityArea></affiliation></author><author><name sortKey="Phair, J P" sort="Phair, J P" uniqKey="Phair J" first="J. P." last="Phair">J. P. Phair</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, Yorkshire</wicri:cityArea></affiliation></author><author><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A." last="Clarke">A. Clarke</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, Yorkshire</wicri:cityArea></affiliation></author><author><name sortKey="Stuart Harris, C H" sort="Stuart Harris, C H" uniqKey="Stuart Harris C" first="C. H." last="Stuart-Harris">C. H. Stuart-Harris</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, Yorkshire</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1977-03">1977</date><biblScope unit="vol">135</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="423">423</biblScope><biblScope unit="page" to="431">431</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Volunteers (15 per group) were given inoculations of various .doses (5–400 international units [IU]) of surface-antigen-adsorbed influenza virus A/Port Chalmers/ 73 vaccine; this vaccine was prepared from purified virus hemagglutinin and neuraminidase antigens and adsorbed to alhydrogel. The titers of hemagglutinationinhibiting (HAl) and neuraminidase-inhibiting antibodies in serum after immunization showed a clear dose-response relationship. Thus, for volunteers given 400, 100, 25, or 5.0 IV of vaccine, the titers of HAl antibody in serum increased 174−, 32−, 12−, and eightfold, respectively. A similar dose response was observed for production of local neutralizing antibody. Immunization with A/Port Chalmers/73 virus vaccine also induced serum HAl antibody to influenza viruses A/Scotland/74, A/England/ 72, and A/Hong Kong/68; the increase in titers of antibody to these viruses corresponded directly to the degree of cross-reactivity between the virus tested and the vaccine virus. Four weeks after immunization, all volunteers were challenged with attenuated WRL-I05 influenza virus. Evidence of viral infection was found in one, two, and two volunteers in each group of IS subjects previously immunized with 400, 100, and 25 IV of vaccine, respectively; in six of the IS volunteers given 5.0 IV of vaccine; and in lOaf 15 control subjects. The results suggest that equivalent immunity was induced in volunteers given ⩾25 IV of vaccine.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></region><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A." last="Clarke">A. Clarke</name><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><name sortKey="Phair, J P" sort="Phair, J P" uniqKey="Phair J" first="J. P." last="Phair">J. P. Phair</name><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><name sortKey="Stuart Harris, C H" sort="Stuart Harris, C H" uniqKey="Stuart Harris C" first="C. H." last="Stuart-Harris">C. H. Stuart-Harris</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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